Endocannabinoid system in neurodegenerative disorders
نویسندگان
چکیده
منابع مشابه
the endocannabinoid system: a putative role in neurodegenerative diseases
conclusions the important role played by endocannabinoid system promises interesting developments, in particular to evaluate the effectiveness of new drugs in both psychiatry and neurology. materials and methods the article is a critical analysis of the most recent data currently present in scientific literature on the subject; a qualitative synthesis of only the most significant articles has b...
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Endocannabinoids are endogenous lipid mediators contributing to a variety of physiological, pharmacological, and pathological processes primarily through acting on cannabinoid receptors (CB1R and CB2R), which are targets of Δ9-tetrahydrocannabinol (Δ9-THC), the major psychoactive ingredient in marijuana.[1] Although N-arachidonoyl ethanolamide is the first identified endocannabinoid, 2-arachido...
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The classical divide between degenerative and inflammatory disorders of the CNS is vanishing as accumulating evidence shows that inflammatory processes are important in the pathophysiology of primarily degenerative disorders, and neurodegeneration complicates primarily inflammatory diseases of the brain and spinal cord. Here, we review the contribution of degenerative and inflammatory processes...
متن کاملTherapeutic implications of the endocannabinoid system in neurodegenerative diseases
Over the last years, considerable progress has been made in understanding the role of the endocannabinoid system in the modulation of several progressive neurodegenerative diseases. The endocannabinoid system, comprised of cannabinoid receptors (type-1 and type-2), their endogenous ligands [referred to as endocannabinoids, of which anandamide (AEA) and 2-arachidonoylglycerol (2-AG) are most stu...
متن کاملThe Endocannabinoid System: A Putative Role in Neurodegenerative Diseases
BACKGROUND Following the characterization of the chemical structure of D9-tetrahydrocannabinol (THC), the main psychoactive constituent of marijuana, researchers have moved on with scientific valuable explorations. OBJECTIVES The aim of this review is to highlight the role of endocannabinoid system in neurodegenerative diseases. MATERIALS AND METHODS The article is a critical analysis of th...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2017
ISSN: 0022-3042
DOI: 10.1111/jnc.14098